IL-27,a member of IL-12/IL-23 heterodimeric family of cytokines,has pleiotropic properties that can enhance or limit immune responses. IL-27 is a heterodimeric cytokine composed of two subunits: IL-27a and IL-27b. IL-27 acts on various cell types,including T cells,B cells,macrophages,dendritic cells,natural killer (NK) cells and non-hematopoietic cells. IL-27 plays a critical role in the early regulation of T helper type 1 initiation,and enhances proliferation of naive CD4+T cells and naive B cells. It,however,also exerts anti-inflammatory functions by inhibiting the development of Th17 cells and inducing IL-10 producing type 1 regulatory T cells. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases.

IL27;IL-27;IL-27A;IL27A;IL27p28;IL30;p28

Human

Detects Human IL-27 in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月