Human CCL13 (MCP-4) was initially identified in a library constructed from human fetal mRNA.  CCL13 shares a high similarity with CCL2 (MCP-1,61%),CCL7 (MCP-3,58%),and CCL8 (MCP-2,55%).  CCL13 is constitutively expressed at high levels in the small intestine,colon,and lung.  Original data showed that CCL13 was less effective than MCP-1 and MCP-3 in monocyte and lymphocyte chemoattraction,but equivalent to eotaxin as a chemoattractant for eosinophils.  Chemokines are very important in the inflammatory process,initially in the influx of PMN by CXC chemokines and subsequently chemoattracting monocytes where the MCPs participate,including CCL13.  The bioactivity of pro-inflammatory chemokines is regulated by MMPs in order to regulate the influx of different cell subpopulations.

SCYA13;MCP-4;NCC-1;SCYL1;CKb10;CCL13;Monocyte chemeotactic protein 4;MCP4;CKβ10;New CC chemokine 1;NCC1;Small inducible cytokine subfamily a,member 13

Human

Detects Human MCP-4 in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月