The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.

CCL4;ACT2;AT744.1;G-26;LAG-1;LAG1;MIP-1-beta;MIP1B;MIP1B1;SCYA4;ACT-2;MIP-1-beta(1-69);C-C motif chemokine 4;chemokine ligand 4;Lymphocyte activation gene 1 protein;Macrophage inflammatory protein 1-beta;MIP1 beta;MIP-1 beta;PAT 744;secreted protein G-26;small inducible cytokine A4;Small-inducible cytokine A4;T-cell activation protein 2

Human

Detects Human MIP-1β in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月