CCL20 (MIP-3a) belongs to the CC chemokine family.    Human CCL20 is a protein of 96 amino acids,which shares the highest homology of 28% amino acid identity with MIP-1ß and 64% amino acid sequence identity with the mouse CCL20.    CCL20 is produced by activated monocytes,T cells,neutrophils,endothelial cells,epithelial cells and fibroblasts.    CCL20 is the ligand for chemokine receptor CCR6,which is expressed on memory T cells,B cells,and immature dendritic cells (DCs).    Therefore,it is involved in the regulation of DC trafficking and recruitment and activation of T cells.    CCL20 also has potent antimicrobial activity.     Upregulation of CCL20 plays important roles in autoimmune pathogenesis of the central nerve system (MS),pathogenesis of encephalomyelitis,psoriasis,rheumatoid arthritis,and inflammatory bowel diseases.    CCL20 is also involved in various cancers,such as gastrointestinal cancers,pancreatic cancer,hepatocellular carcinoma,and breast cancer.

CCL20;CKb4;LARC;MIP3A;SCYA20;ST38

Human

Detects Human MIP-3α in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月