Type I collagen is the most abundant structural protein of connective tissues such as skin,bone and tendon. It is synthesized as a procollagen molecule which is characterized by a 300 nm triple helical domain flanked by globular N- and C-terminal propeptides (1). The triple helical domain contains Gly-Xaa-Yaa triplets where Xaa and Yaa are frequently proline and hydroxyproline,respectively. The non-helical propeptides are removed by procollagen N- and C-proteinase activities so that the mature triple helices can self-assemble into collagen fibrils that provide tensile strength to tissues (1). Type I collagen is a heterotrimer that consists of two alpha 1(I) chains and one alpha 2(I) chain,although homotrimers consisting of three identical alpha 1(I) chains have also been described (2). This recombinant mini pro-alpha 1(I) collagen consists of a shortened alpha 1(I) chain with following domain structure from N- to C-terminus: N-propeptide,N telopeptide,the 33 most N-terminal Gly-Xaa-Yaa repeats,the 33 most C-terminal Gly-Xaa-Yaa repeats,C-telopeptide and C-propeptide. The preparation contains a mixture of the full-length molecule,pN collagen I( alpha 1) and the C-terminal propeptide. This truncated pro-alpha 1(I) collagen is a substrate for procollagen N-proteinase and procollagen C-proteinase.

COL1A1;EDSC;OI1;OI2;OI3;OI4;PINP;PICP;COL1;CTXI;COL1α1;Cross Linked C-telopeptide of Type Ⅰ Collagen;Cross Linked N-telopeptide of Type Ⅰ Collagen;Procollagen Ⅰ C-Terminal Propeptide;Collagen alpha-1(I) chain;NTX I;Alpha-1 type I collagen

Human

Detects Human PⅠNP in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月