Programmed cell death ligand 1 ( CD274;or B7-H1;PD-L1 ) ;is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors;the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell;and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal;essential for T-cell proliferation and production of IL10 and IFNG;in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa;the apparent molecular weight has been reported as 45-70 kDa;suggesting probable glycosylation .

CD274;B7-H1;PD-L1;PDCD1L1;PDL1;B7 homolog 1

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月