Human SIRT1 Antibody Pair Set
Price:
Size:
50 μL&100 μg
- 反应性： Human
| Background |
SIRT1,the human homolog of the S. cerevisiae Sir2 protein,functions as an NAD-dependent deacetylase of a number of nonhistone substrates including p53. In response to DNA damage,SIRT1 binds and deacetylates the p53 protein at c-terminal Lys382 residue and attenuates p53-mediated functions. When overexpressed in mouse embryo fibroblasts,SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. In mammalian cells,SIRT1 appears to control the cellular response to stress by regulating the FOXO family of forkhead transcription factors.
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| Synonyms |
SIR2L1;NAD-dependent deacetylase sirtuin-1
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human SIRT1 in ELISAs
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| Buffer |
Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
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| Storage |
-20℃
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| Expiration date |
12个月
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