This gene encodes a member of the ADAM ( a disintegrin and metalloprotease domain ) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins , and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions , including fertilization , muscle development , and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha , in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates , including cell adhesion proteins , cytokine and growth factor receptors and epidermal growth factor ( EGF ) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis , rheumatoid arthritis , multiple sclerosis and Crohn's disease patients , suggesting that the encoded protein may play a role in autoimmune disease.

ADAM metallopeptidase domain 17;ADAM17;TACE;tumor necrosis factor-α-converting enzyme;ADAM18;CD156B;CSVP;NISBD;

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月