Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD , and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation , survival and migration of endothelial cells , and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC , and to a lesser degree VEGFA , thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades , isoform 2 seems to be less efficient in signal transduction , because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2 , MAPK3/ERK1 signaling pathway , of MAPK8 and the JUN signaling pathway , and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1 , the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185' , and of AKT1 at 'Ser-473'

FLT41;PCL;LMPH1A

Human

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月