The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains , both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein ( APP ) . Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease , the most common cause of dementia. Overexpression of the encoded protein , which is a member of the peptidase C1 family , has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.

APPS;CPSB

Monkey

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月