ACPP,also known as prostatic acid phosphatase,belongs to the histidine acid phosphatase family.    It has phosphotyrosyl phosphatase activity.    It is predominantly expressed in the prostate gland,and restricted to gladular and ductal epithelial cells,and mainly in the secreted form.    It is also widely expressed in non-prostatic tissues,such as bladder,kidney,pancreas,lung,cervix,testis,and ovary,as a type I transmembrane protein with N-terminal phosphatase activity.    The expression of ACPP correlates with prostate cell proliferation.    High levels of ACPP leads to slow cell growth.    Though the level of ACPP in the circulation is increased in prostate cancer patients,its level and activity are reduced in prostate cancer cells.    ACPP serves as a tumor suppressor.    Reduced ACPP levels result in hyperphosphorylation of HER-2 (human epidermal growth factor receptor-2),activating downstream MAPK signaling,prostate cancer progression and androgen-independent growth.    In addition,ACPP dephosphorylates ErbB-2,blocking downstream ERK1/2 and AKT signaling and tumorigenicity.

ACPP;5'-NT;ACP-3;ACP3;acid phosphatase,prostate

Mouse

Detects Mouse ACP3/PAP in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月