Alkaline phosphatases function physiologically as homodimers.  They catalyze the hydrolysis of phosphomonoesters and release inorganic phosphate.  In humans,four isoenzymes have been described: a tissue-nonspecific (TNAP) and three tissue-specific placental (PLAP),intestinal (IAP),and germ cell (GCAP).  TNAP is a cell membrane-bound ecto-enzyme that releases inorganic phosphate from phosphate-enriched substrates.  Also,ALPL induces the hydrolysis of extracellular inorganic pyrophosphate (PPi) which is a potent endogenous inhibitor of calcification both in vivo and in vitro.  Increased activity of the enzyme alkaline phosphatase is associated with lower levels of PPi and vascular calcification present in patients with chronic kidney disease.

ALPL;AP-TNAP;APTNAP;HOPS;TNAP;TNSALP;alkaline phosphatase;liver/bone/kidney;TNALP

Mouse

Detects Mouse ALPL in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月