Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilic manner in connecting cells , cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions , mobility and proliferation of epithelial cells.Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. Does not function as a receptor for L.monocytogenes internalin A ( InlA ) , mutating a single surface-exposed residue confers receptor activity to this protein and promotes uptake of the bacteria.

CDH1;Arc-1;CD324;CDHE;LCAM;UVO;CAM 120/80;Epithelial Cadherin;Uvomorulin

Mouse

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月