Interleukin-18 ( L-18 ) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor , and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide ( LPS ) . After stimulation with IL-18 , natural killer ( NK ) cells and certain T cells release another important cytokine called interferon-γ ( IFN-γ ) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production , and enhance IgG2a production in B cells. IL-18 binding protein ( IL18BP ) can specifically interact with this cytokine , and thus negatively regulate its biological activity.

IL18;IGIF;IL-1g;IL-1F4;Interferon-gamma-inducing factor

Mouse

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月