Interleukin-3 (lL-3) is a hemopoietic growth factor involved in the survival,proliferation,and differentiation of multipotent hemopoietic cells. In addition to granulocyte-macrophage colony-stimulating factor (GMCSF) and IL-5,IL-3 is the most potent growth factor for basophils. On mature basophils,these three cytokines act through specific receptors mediating adhesion,migration,and releasability. Mast cells expresses high amounts of IL-3. In the absence of antigen,rapid release of large amount of IL-3 in an autocrine dependent manner is responsible for mast cell survival. IL-3 plays a vital role in stimulating basophils and mast cell responses to parasite infections. IL-3 has also been implicated in the pathogenesis of several chronic inflammatory diseases,including asthma,atherosclerosis,and neurodegenerative disorders,such as multiple sclerosis.  IL-3 stimulates colony formation of megakaryocytes,neutrophils,and macrophages from bone marrow cultures. IL-3 is expressed in the major embryonic vessels and regulates the survival and proliferation of hematopoietic stem cells in the early stages of embryonic development.

IL3;MCGF;MCSF;MULTI-CSF;P-Cell Stimulating Factor

Mouse

Detects Mouse IL-3 in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月