Cytokine secreted primarily by mast cells , T-cells , eosinophils , and basophils that plays a role in regulating antibody production , hematopoiesis and inflammation , and the development of effector T-cell responses.Induces the expression of class II MHC molecules on resting B-cells.Enhances both secretion and cell surface expression of IgE and IgG1.Regulates also the expression of the low affinity Fc receptor for IgE ( CD23 ) on both lymphocytes and monocytes.Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.In addition , plays a critical role in higher functions of the normal brain , such as memory and learning.Upon binding to IL4 , IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex , located mainly on hematopoietic cells , or with the IL13RA1 to produce the type 2 complex , which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.

IL4;BCGF-1;BCGF1;BSF-1;BSF1

Mouse

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月