Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival , differentiation , and chemotaxis of eosinophils.Acts also on activated and resting B-cells to induce immunoglobulin production , growth , and differentiation.Mechanistically , exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN , SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.

IL5;EDF;TRF;E-CSF;ESGF

Mouse

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月