XCL1,also known as lymphotactin,is an inflammatory chemokine secreted by T cells and natural killer (NK) cells.  Early reports described XCL1 as a mediator of T cell and NK cell migration,but recent studies suggest a highly specialized role for XCL1 and its receptor XCR1.  The XCL1-XCR1 axis has been shown to play an important role in the dendritic cell mediated cytotoxic immune response and in the formation of self-tolerance mechanisms through the development of regulatory T cells within the thymus.  XCL1 also acts as a conformation-dependent inhibitor of HIV-1.  Unlike other chemokines,XCL1 conformation interchanges between conserved chemokine folds and an unrelated dimeric structure under physiological conditions.

SCYC1;LTN;ATAC;SCM-1a;SCM-1

Mouse

Detects Mouse Lptn/XCL1 in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月