NOV (CCN3) is a member of the CCN family of secreted,cysteine-rich regulatory proteins that share four conserved modules which confer distinct biological activities.   These modules include an insulin-like growth factor binding domain,a von Willebrand type C domain,thrombospondin-1 domain,and a C-terminal cysteine knot domain.   It is widely expressed developmentally,especially in the muscle,endothelium,nervous system,adrenal cortex,and chondrocytes.   NOV (CCN3) acts through the Notch and BMP signaling pathways to modulate self-renewal and maturation of a number of cell lineages including hematopoietic,osteogenic,and chondrogenic lineages.   NOV (CCN3) is also a putative ligand for integrin receptors and is tightly associated with the extracellular matrix.   Its interaction with integrins alpha v beta 3 and alpha 5 beta 1 mediates endothelial cell adhesion induces chemotaxis and promotes angiogenesis.   The elevated expression of NOV (CCN3) is associated with certain tumors such as Wilm’s tumor and most nephroblastomas.

CCN3;IGFBP9;NOVH;IBP-9;Insulin-like growth factor-binding protein 9;Protein NOV homolog

Mouse

Detects Mouse NOV in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月