Receptor that mediates the recognition,internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells.  OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction,resulting in pro-inflammatory responses,pro-oxidative conditions and apoptosis.  Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release,monocyte adhesion and apoptosis.  In addition to binding oxLDL,it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells,thereby participating in cell-mediated antigen cross-presentation.  Also involved in inflammatory process,by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.  Also acts as a receptor for advanced glycation end (AGE) products,activated platelets,monocytes,apoptotic cells and both Gram-negative and Gram-positive bacteria.

CLEC8A;CLEC8ASLOX1;C-type lectin domain family 8 member A;hLOX-1;Lectin-like oxidized LDL receptor 1;Lectin-like oxLDL receptor 1;Lectin-type oxidized LDL receptor 1;LOX1;LOX-1;LOX1ox LDL receptor 1;LOXIN;OLR1

Mouse

Detects Mouse OxLDL in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月