PDGF-BB is a mitogen that was initially identified as simian sarcoma viral oncogene homolog.     It belongs to the Platelet-Derived Growth Factor (PDGF) family which includes five members: PDGF-AA,PDGF-BB,PDGF-AB,PDGF-CC,and PDGF-DD.     PDGF-AA,AB,and BB dimers are processed intracellularly and secreted as active dimers that readily activate PDGF receptors (PDGFRs).    PDGF-BB exerts its biological functions through the activation of dimeric receptors that are made up of two structurally similar protein-tyrosine kinase receptor subunits (αα-,αβ-,or ββ-PDGFR).    PDGF-BB induces VSMC dedifferentiation by the down regulation of contractile protein markers and the up regulation of MMP-2.     In cutaneous remodeling,studies ex vivo revealed that PDGF-BB is a mitogen and chemoattractant for dermal fibroblasts.     Abnormalities of PDGFR/PDGF are thought to contribute to a number of human diseases,especially malignancy.     Autocrine signaling is a consequence of PDGF-BB overexpression,which is clearly implicated in the pathogenesis of dermatofibrosarcoma protruberans (DFSP).

c-sis;IBGC5;PDGF2;PDGF-2;PDGFB;Platelet-derived growth factor subunit B;SIS;SSV;PDGFBB;PDGF-BB

Mouse

Detects Mouse PDGF-BB in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月