This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor ( TF ) -dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex , which proteolytically activates additional proteases ( factors IX and X ) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity , specificity and cellular localization.

EPI;LACI;TFI;TFPI1;lipoprotein-associated coagulation inhibitor

Porcine

PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5; PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5

-20℃

12个月