Purified Anti-Human CD192 Antibody[K036C2]
![Purified Anti-Human CD192 Antibody[K036C2]](http://files.elabscience.cn/assets/images/loading.png)
Price:
Size:
100 μg
25 μg
- 应用性： FCM
- 亚型： Mouse IgG2a, κ
- 宿主： Mouse
| Alternate Names | CKR, CMKBR, CC-CKR, CCR, CCR2, CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, FLJ78302, C C chemokine receptor type 2, C C CKR 2, CC chemokine receptor type 2, C-C chemokine receptor type 2, CC CKR 2, C-C CKR-2, CCCKR2, CCR 2, CCR1L, CCR5L, CD192 antigen, Chemokine C C motif receptor 2, Chemokine CC Motif Receptor 2, CKR 2, cluster of differentiation 192, MCP 1 R, MCP1 RECEPTOR, MCP1R, MCP-1-R, Monocyte chemoattractant protein 1 receptor, Monocyte Chemotactic Protein 1 Receptor |
| Clone No | |
| Isotype | Mouse IgG2a, κ |
| Leadtime |
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| Verified Samples | Verified Samples in FCM: Human peripheral blood monocytes cell |
| Dilution |
FCM 2 μg/mL(1×105-5×105 cells)
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| Background |
CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.
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| Immunogen | Recombinant Human CD192 protein |
| Abbre | CD192 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Applications | |
| Research Areas | Immunology;Microbiology;Signal Transduction;Cancer;Cardiovascular |
| Concentration | ≥ 1 mg/mL |
| Conjugation | Unconjugated |
| Storage Buffer | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12个月 |
| Shipping |
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Human peripheral blood monocytes cell were stained with 0.2 μg Purified Anti-Human CD192 Antibody[K036C2] (Right) and 0.2 μg Mouse IgG2a, κ Isotype Control (Left), followed by Alexa Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
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