Purified Anti-Human CD243 Antibody[15D3]
![Purified Anti-Human CD243 Antibody[15D3]](http://files.elabscience.cn/assets/images/loading.png)
Price:
Size:
100 μg
25 μg
- 应用性： FCM
- 亚型： Mouse BALB/c IgG1, V-KAPPA
- 宿主： Mouse
| Alternate Names | MDR, PGY, ABC, ABCB, P-glycoprotein, Phospholipid transporter ABCB, ATP-dependent translocase ABCB, ATP-binding cassette sub-family B member, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, P Glycoprotein, ABCB1, ATP-binding cassette sub-family B member 1, ATP-dependent translocase ABCB1, P-glycoprotein 1, Phospholipid transporter ABCB1, MDR-1, P-gp, gp170, ABC-B1, ATP binding cassette, Colchicin sensitivity, Doxorubicin resistance, member 1, Multidrug resistance 1, Multidrug resistance protein 1, P glycoprotein 1, P gp, sub family B (MDR/TAP) |
| Clone No | |
| Isotype | Mouse BALB/c IgG1, V-KAPPA |
| Leadtime |
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| Verified Samples | Verified Samples in FCM: Human peripheral blood lymphocytes |
| Dilution |
FCM 2 μg/mL(1×105-5×105 cells)
|
| Background |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
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| Immunogen | Recombinant Human CD243 protein |
| Abbre | CD243 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Applications | |
| Research Areas | Signal Transduction;Stem Cells;Cancer |
| Concentration | ≥ 1 mg/mL |
| Conjugation | Unconjugated |
| Storage Buffer | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12个月 |
| Shipping |
Ice bag |
Human peripheral blood lymphocytes were stained with 0.2 μg Purified Anti-Human CD243 Antibody[15D3] (Right) and 0.2 μg Mouse IgG1, κ Isotype Control (Left), followed by Alexa Fluor® 647-conjugated Goat Anti-Mouse IgG Secondary Antibody.
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