Purified Anti-Human CD279/PD-1 Antibody[J116]
![Purified Anti-Human CD279/PD-1 Antibody[J116]](http://files.elabscience.cn/assets/images/loading.png)
Price:
Size:
100 μg
25 μg
- 应用性： FCM
- 亚型： Mouse IgG1, κ
- 宿主： Mouse
| Alternate Names | Programmed Death-1, PD-1 |
| Clone No | |
| Isotype | Mouse IgG1, κ |
| Leadtime |
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| Background |
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
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| Abbre | CD279/PD-1 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Applications | |
| Research Areas | Cancer Biomarkers;Immunology;Inhibitory Molecules |
| Concentration | ≥ 1 mg/mL |
| Conjugation | Unconjugated |
| Storage Buffer | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12个月 |
| Shipping |
Ice bag |
| E-AB-F11290 | AF/LE Purified Anti-Human CD279/PD-1 Antibody[J116] | 100 μg , 25 μg |
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