TKR, ERBB, erb-b2 receptor tyrosine kinase, Receptor tyrosine-protein kinase erbB, Tyrosine kinase-type cell surface receptor HER, HER2/ErbB, HER, MLN, ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2, HER2/ErbB2, MLN19, Metastatic lymph node gene 19 protein, p185, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2,  Neu,  erb-B2, CD340, erb-b2 receptor tyrosine kinase 2, HER2, HER-2, HER-2/neu, MLN 19, MLN19, NGL, TKR1, C erb B2/neu protein, CD340 antigen, Cerb B2/neu protein, CerbB2, ENV, ENVW, Erb b2 receptor tyrosine kinase 2, ERVWE1, HER 2, HER 2/NEU, Herstatin, HERV7Q, HERV-7q, HERVW, HERVWENV, HERV-W-ENV, Human epidermal growth factor receptor 2, NEU proto oncogene, neuro/glioblastoma derived oncogene homolog, neuro/glioblastoma derived oncogene homolog (avian), Neuroblastoma/glioblastoma derived oncogene homolog, p185erbB2, Proto-oncogene c-ErbB-2, Tyrosine kinase type cell surface receptor HER2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), V erb b2 avian erythroblastic leukemia viral oncoprotein 2, V erb b2 erythroblastic leukemia viral oncogene homolog 2, Verb b2 erythroblastic leukemia viral oncogene homolog 2

chA21

Mouse IgG2a, κ

咨询

FCM 2 μg/mL(1×10⁵-5×10⁵ cells)

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

CD340

Mouse

Human

Monoclonal

>98%, Protein A/G purified

FCM

≥ 1 mg/mL

Unconjugated

PBS, pH 7.2. Contains 0.05% proclin 300.

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

12个月

Ice bag