Purified Anti-Mouse CD23 Antibody[B3B4]
![Purified Anti-Mouse CD23 Antibody[B3B4]](http://files.elabscience.cn/assets/images/loading.png)
Price:
Size:
100 μg
25 μg
- 应用性： FCM
- 亚型： Rat IgG2a, κ
- 宿主： Rat
| Alternate Names | Fce, FCER, CD23, Fce2, Fc-epsilon-RII, Ly-42, Lymphocyte IgE receptor, Fcer2a, Fcer2, Fc&, epsilon-RII-I, Ly-42, BLAST-2, CD23A, CLEC4J, Fc epsilon RII, IGEBF |
| Clone No | |
| Isotype | Rat IgG2a, κ |
| Leadtime |
咨询
|
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse splenocytes |
| Dilution |
FCM 2 μg/mL(1×105-5×105 cells)
|
| Background |
CD23, also known as FcεRII, is a trimeric type II transmembrane glycoprotein member of the calcium-dependent (C-type) lectin family. CD23 is expressed in B and T lymphocytes, monocytes, polymorphonuclear leukocytes, follicular dendritic cells, intestinal epithelial cells, and bone marrow stromal cells. CD23 was first identified as a low-affinity receptor for IgE and the engagement of membrane bound CD23 leads to suppressed IgE production by B lymphocytes. CD23 can be cleaved to form a soluble protein which can drive cytokine release in monocytic cells, nitric oxide (NO) production, and the synthesis of cyclic adenosine 3′5′-monophosphate (cAMP). Soluble CD23 signals through integrins, activating MAPK and NF-κB pathways. CD23 is a useful marker in the prognosis of neoplastic disease, is elevated in a variety of autoimmune and inflammatory conditions, and is being investigated as a therapeutic target for IgE-mediated allergy, arthritis, and B cell chronic lymphocytic leukemia (CLL).
|
| Immunogen | Recombinant Mouse CD23 protein |
| Abbre | CD23 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Applications | |
| Concentration | ≥ 1 mg/mL |
| Conjugation | Unconjugated |
| Storage Buffer | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12个月 |
| Shipping |
Order now, ship in 3 days |
C57/BL6 Mouse splenocytes were stained with 0.2 μg Purified Anti-Mouse CD23 Antibody[B3B4] (Right) and 0.2 μg Rat Ig2a, κ Isotype Control (Left), followed by Alexa Fluor® 647-conjugated Goat Anti-Rat IgG Secondary Antibody, then anti-Mouse B220 PE-conjugated Monoclonal Antibody.
积分商城
微信公众号
