ICAM-1 (intercellular adhesion molecule-1),also known as CD54,is a transmembrane protein that is upregulated on endothelial and epithelial cells at sites of inflammation. It mediates the vascular adhesion and paracellular migration of leukocytes expressing activated LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It also binds several non-integrin ligands including CD43/Sialophorin,Fibrinogen,Hyaluronan,rhinoviruses,and Plasmodium falciparum-infected erythrocytes. Soluble ICAM-1 promotes angiogenesis and serves an indicator of vascular endothelial cell activation or damage. Elevated levels of soluble ICAM-1 are associated with cardiovascular disease,type 2 diabetes,organ transplant dysfunction,oxidant stress,increased abdominal fat mass,hypertension,liver disease,certain malignancies,and cerebral malaria.

Icam1;CD54;intercellular adhesion molecule 1;Icam-1

Rat

Detects Rat ICAM-1/CD54 in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月