CD14 is a pattern recognition receptor important in innate immunity.    CD14 exists in two forms,as a glycosylphosphatidylinositol-anchored protein on the surface of mononuclear cells and as a soluble protein in the blood.    CD14 is shed from the surface of CD14-expressing cells,resulting in the soluble CD14 protein (sCD14).    CD14 is down regulated from the cell membrane on stimulated monocytes by different factors such as LPS,IFNγ,PMA,calcium ionophore A 23187,and antibodies against CD14.    CD14 can be released from the cells with GPI-phospholipase C and D (PLC/D).    Membrane associated CD14 is a pro-inflammatory co-receptor for LPS,a characteristic constituent of the cell wall of Gram-negative bacteria.   Elevated levels of sCD14 has been detected in serum of patients with different diseases such as systemic lupus erythematosus,HIV infected patients,common variable immunodeficiency (CVID),and nonalcoholic fatty liver disease (NAFLD).    Also,high levels of sCD14 have been associated with infectious diseases,including sepsis.

CD14 Antigen;Monocyte Differentiation Antigen CD14

Rat

Detects Rat sCD14 in ELISAs

Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4; Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4

-20℃

12个月