Recombinant Cynomolgus Interleukin-17A/IL-17A (C-6His)-Elabscience伊莱瑞特【官网】

Recombinant Cynomolgus Interleukin-17A/IL-17A (C-6His)

一键复制产品信息

货号：PKSQ050109
说明书

说明书

Recombinant Cynomolgus Interleukin-17A/IL-17A (C-6His)

Price: ¥2940.00 ¥966.00

Size:

50 μg 10 μg

表达系统： HEK293 Cells
蛋白编码： G7P4U9
应用性： ELISA

别称	CTLA-8;CTLA8;Cytotoxic T-Lymphocyte-Associated Antigen 8;IL-17;IL-17A;IL17;IL17A;Interleukin-17A
表达系统	HEK293 Cells
序列	Gly24-Ala155
蛋白编码	G7P4U9
种属	Cynomolgus macaques
计算分子量	15.9 kDa
表观分子量	15-25 kDa
标签	C-His
生物活性	Immobilized Cynomolgus IL-17A-His (Cat#PKSQ050109) at 10 μg/ml (100 μl/well) can bind Anti-Human IL-17A mAb. The ED50 of Anti-Human IL-17A mAb is 128 ng/ml.
纯度	> 95 % as determined by reducing SDS-PAGE.
内毒素	< 1.0 EU per μg of the protein as determined by the LAL method.
保存条件	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输条件	This product is provided as lyophilized powder which is shipped with ice packs.
制剂	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
复溶方法	Please refer to the printed manual for detailed information.
背景	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

> 95 % as determined by reducing SDS-PAGE.

Immobilized Cynomolgus IL-17A-His (Cat#PKSQ050109) at 10 μg/ml (100 μl/well) can bind Anti-Human IL-17A mAb. The ED50 of Anti-Human IL-17A mAb is 128 ng/ml.