Recombinant Cynomolgus Interleukin-17A/IL-17A (C-6His)（PKSQ050109）|-Elabscience伊莱瑞特【官网】

Recombinant Cynomolgus Interleukin-17A/IL-17A (C-6His)

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货号：PKSQ050109
说明书

说明书

Recombinant Cynomolgus Interleukin-17A/IL-17A (C-6His)

Price: ¥2940.00 ¥966.00

Size:

50 μg 10 μg

表达系统： HEK293 Cells
蛋白编码： G7P4U9
应用性： ELISA

别称	CTLA-8;CTLA8;Cytotoxic T-Lymphocyte-Associated Antigen 8;IL-17;IL-17A;IL17;IL17A;Interleukin-17A
表达系统	HEK293 Cells
序列	Gly24-Ala155
蛋白编码	G7P4U9
种属	Cynomolgus macaques
计算分子量	15.9 kDa
表观分子量	15-25 kDa
标签	C-His
生物活性	Immobilized Cynomolgus IL-17A-His (Cat#PKSQ050109) at 10 μg/ml (100 μl/well) can bind Anti-Human IL-17A mAb. The ED50 of Anti-Human IL-17A mAb is 128 ng/ml.
纯度	> 95 % as determined by reducing SDS-PAGE.
内毒素	< 1.0 EU per μg of the protein as determined by the LAL method.
保存条件	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输条件	This product is provided as lyophilized powder which is shipped with ice packs.
制剂	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
复溶方法	Please refer to the printed manual for detailed information.
背景	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

> 95 % as determined by reducing SDS-PAGE.

Immobilized Cynomolgus IL-17A-His (Cat#PKSQ050109) at 10 μg/ml (100 μl/well) can bind Anti-Human IL-17A mAb. The ED50 of Anti-Human IL-17A mAb is 128 ng/ml.

Q1:重组蛋白有活性吗？可以做活性检测吗？

活性说明的见说明书bio-activity部分；如果说明书显示没有生物活性或则显示生物活性检测中，则说明这个蛋白没有生物活性数据，需要客户自己检测。

Q2:重组蛋白是否测序验证过？

在售重组蛋白默认不做测序分析/验证。

Q3:蛋白的运输条件是什么？

我们的蛋白有液体和冻干粉2种形式，一般来说冻干粉可以用冰袋、蓝冰、干冰运输；液体可以用蓝冰或干冰运输。

Q4:蛋白是通过什么方式纯化的？

一般通过纯化标签进行亲和纯化，常规有镍柱/His Tag、protein AG/Fc tag、标签抗体凝胶等。

Q5:蛋白可以用于细胞培养/注射小鼠吗？

内毒素含量小于0.1 ng/μg (1 EU/μg)的蛋白都可以用于细胞培养/注射小鼠。

Q6:蛋白发货形式可以是冻干粉吗？可以发液体吗？

默认按照说明书标注的形式发货；如果有特殊需求，需要根据蛋白情况确定。原则上，冻干粉蛋白可以发液体形式，液体蛋白不能发冻干粉形式。