Recombinant Human ACE2 Protein (Fc Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： Q9BYF1
- 应用性： ELISA
| 别称 |
ACE-Related Carboxypeptidase;ACE2;ACEH;Angiotensin-Converting Enzyme 2;Angiotensin-Converting Enzyme Homolog;Metalloprotease MPROT15
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| 表达系统 |
HEK293 Cells
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| 序列 |
Gln18-Ser740
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| 蛋白编码 |
Q9BYF1
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| 种属 |
Human
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| 计算分子量 |
110.5 kDa
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| 表观分子量 |
110-140 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Immobilized Human ACE-2-Fc(Cat#PKSR030492) at 2μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-SD1-mFc(Cat#PKSR030476). The ED50 of Recombinant 2019-nCoV S Protein RBD-mFc(Cat#PKSR030476) is 15.5 ng/ml.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris–HCl, 300mM NaCl, 10% Glycerol, 100mM Glycine, pH7.4.
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| 复溶方法 |
Not Applicable
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| 背景 |
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
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Targeting the Neuropilin-1 receptor with Ovatodiolide and progress in using periodontal ligament organoids for COVID-19 research and therapy
IF: 5.200Journal： LIFE SCIENCES (2024)
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