Recombinant Human ALK-1 Protein(Fc Tag)
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- 表达系统： Mammalian
- 蛋白编码： P37023
| 别称 |
SKR;ORW;Activin Receptor-Like Kinase;Serine/Threonine-Protein Kinase Receptor R;ACVRL;ACVRLK;ALK;ACVRL1;ACVRLK1;ALK-1;ALK1;HHT;HHT2;ORW2;SKR3;TSR-I;Activin Receptor-Like Kinase 1;Serine/Threonine-Protein Kinase Receptor R3;TGF-B Superfamily Receptor Type I
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| 表达系统 |
Mammalian
|
| 序列 |
Asp22-Gln118
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| 蛋白编码 |
P37023
|
| 种属 |
Human
|
| 计算分子量 |
35.5 kDa
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| 表观分子量 |
50 kDa
|
| 标签 |
C-Fc
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| 生物活性 |
Not validated for activity
|
| 纯度 |
> 90% as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU/mg of the protein as determined by the LAL method
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
Activin A receptor , type II-like 1 (ACVRL1) , also known as ALK-1 (activin receptor-like kinase 1) , is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding , a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney , spleen , heart and intestine , serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2 , also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
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实验操作视频
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