Recombinant Human BDNF Protein (with pro peptide)
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- 表达系统： E.coli
- 蛋白编码： P23560
| 别称 |
Abrineurin;BDNF;Brain-Derived Neurotrophic Factor
|
| 表达系统 |
E.coli
|
| 序列 |
Ala19-Arg247(R125A,R127A,R128A)
|
| 蛋白编码 |
P23560
|
| 种属 |
Human
|
| 计算分子量 |
25.6 kDa
|
| 表观分子量 |
28 kDa
|
| 标签 |
None
|
| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 100mM NaCl, 0.02% Tween 80, pH 6.0.
|
| 复溶方法 |
Not Applicable
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| 背景 |
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis; whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival; growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects; Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
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实验操作视频
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