Recombinant Human BRCA2 Protein (His Tag)
Price:
- 表达系统： E.coli
- 蛋白编码： P51587-1
- 应用性： Immunogen
| 别称 |
BRCA 2;BRCA1/BRCA2 containing complex subunit 2;BRCA2;BRCC 2;BRCC2;Brca2;Breast Cancer 2 t;Breast and ovarian cancer susceptibility gene early onset;Breast cancer 2 early onset;DNA repair associated;breast and ovarian cancer susceptibility protein 2
|
| 表达系统 |
E.coli
|
| 序列 |
Thr2350-Val2545
|
| 蛋白编码 |
P51587-1
|
| 种属 |
Human
|
| 计算分子量 |
22.1 kDa
|
| 表观分子量 |
25.4 kDa
|
| 标签 |
N-His
|
| 生物活性 |
Not validated for activity
|
| 纯度 |
> 85% as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 10 EU/mg of the protein as determined by the LAL method
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
|
| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
|
| 背景 |
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
|
实验操作视频
新品推荐
Recombinant Mouse CXCL1 Protein(GST Tag)
Recombinant Human BCL2 Protein(GST Tag)
Recombinant Mouse Agrp Protein(GST Tag)
Recombinant Human S100A9 Protein(Trx Tag)
Recombinant Mouse Ceacam1 Protein(His Tag)
Recombinant Mouse Fetuin-A Protein(His Tag)
Recombinant Mouse CD3E Protein(Trx Tag)
Recombinant Human CD44 Protein(Trx Tag)
联系我们
