Recombinant Human BRD4 (N-10His-Flag)
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- 表达系统： E.coli
- 蛋白编码： O60885
| 别称 |
HUNK1;HUNK1bromodomain-containing protein 4;HUNKI;MCAP
|
| 表达系统 |
E.coli
|
| 序列 |
Glu49-Glu460
|
| 蛋白编码 |
O60885
|
| 种属 |
Human
|
| 计算分子量 |
49.0 kDa
|
| 表观分子量 |
55-60 kDa
|
| 标签 |
N-His-Flag
|
| 生物活性 |
Not validated for activity
|
| 纯度 |
> 90 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 50mM HEPES, 200mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5.
|
| 复溶方法 |
Not Applicable
|
| 背景 |
Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. BRD bromodomains serve as recognition motifs for acetylated lysine residues on histones, while the NET domain may function by promoting phosphorylation of the C-terminal domain (CTD) of RNA Polymerase II. Some specific inhibitors of BRD4 that prevent binding to acetylated histones by binding Asn-140 and Asn-433 are promising therapeutic molecules for the treatment of leukemias. BRD4 is a potential therapeutic target in many diseases including breast cancer, AML, multiple myeloma, colon cancer and others.
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实验操作视频
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