Recombinant Human c-KIT/CD117 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P10721
| 别称 |
CD117;Mast/stem cell growth factor receptor Kit;PBT;Piebald trait protein;Proto-oncogene c-Kit;SCFR;Tyrosine-protein kinase Kit;p145 c-kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
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| 表达系统 |
HEK293 Cells
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| 序列 |
Gln26-Thr520
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| 蛋白编码 |
P10721
|
| 种属 |
Human
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| 计算分子量 |
56.5 kDa
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| 表观分子量 |
150 kDa
|
| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.
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Antibody-Drug Conjugate Targeting c-Kit for the Treatment of Small Cell Lung Cancer
IF: 6.208 -
Development and characterization of a fully human antibody targeting SCF/c-kit signaling
IF: 5.162Journal： INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)PMID：32437800
实验操作视频
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