Recombinant Human Cadherin-11/CDH11 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： Q96CZ9
| 别称 |
CDH11;Cadherin 11 Type 2 OB-Cadherin (Osteoblast) Isoform CRA_c;Cadherin 11 Type 2 OB-cadherin (Osteoblast)
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| 表达系统 |
HEK293 Cells
|
| 序列 |
Phe23-Thr617
|
| 蛋白编码 |
Q96CZ9
|
| 种属 |
Human
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| 计算分子量 |
66.6 kDa
|
| 表观分子量 |
82 kDa
|
| 标签 |
C-His
|
| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
|
| 背景 |
Cadherin-11 is a type II classical cadherin member of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells; and thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in the brain. Mature cadherin proteins consists of a large N-terminal extracellular domain; a single membrane-spanning domain; and a small highly conserved C-terminal cytoplasmic domain. It is shown that Cadherin-11 is a viable molecular target for therapeutic intervention in Glioblastoma multiforme.
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Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody
IF: 12.779Journal： PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)PMID：36256815
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