Recombinant Human CCL2/MCP-1 Protein
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- 表达系统： E.coli
- 蛋白编码： P13500
- 应用性： Cell culture
| 别称 |
C-C motif chemokine 2;CCL2;HC11;MCAF;MCP-1;Monocyte chemoattractant protein 1;Monocyte chemotactic and activating factor;Monocyte chemotactic protein 1;Monocyte secretory protein JE;Small-inducible cytokine A2
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| 表达系统 |
E.coli
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| 序列 |
Gln24-Thr99
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| 蛋白编码 |
P13500
|
| 种属 |
Human
|
| 计算分子量 |
9.5 kDa
|
| 表观分子量 |
11 kDa
|
| 标签 |
N-His
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| 生物活性 |
Measure by its ability to chemoattract BaF3 cells transfected with human CCR2A.The ED50 for this effect is <20 ng/mL.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 0.1 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from sterile PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention.
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A label-free AuNPs-based ultrasensitive plasmonic ELISA by alkaline phosphatase and ferrous ion-initiated cascade amplification
IF: 8.400Journal： SENSORS AND ACTUATORS B-CHEMICAL (2023)
实验操作视频
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