Recombinant Human CD155/PVR/NECL5 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： NP_006496
- 应用性： BLI
| 别称 |
CD155;NECL-5;Nectin-Like Protein 5;PVR;PVS;Poliovirus Receptor
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| 表达系统 |
HEK293 Cells
|
| 序列 |
Trp21-Asn343
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| 蛋白编码 |
NP_006496
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| 种属 |
Human
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| 计算分子量 |
36.1 kDa
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| 表观分子量 |
58 kDa
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| 标签 |
C-His
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| 生物活性 |
Loaded Human TIGIT-Fc on Protein A Biosensor, can bind Human PVR-His with an affinity constant of 4.22 nM as determined in BLI assay.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
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| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
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| 复溶方法 |
Not Applicable
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| 背景 |
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.
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实验操作视频
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