Recombinant Human CD19/Leu-12 Protein (Fc Tag)
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- 表达系统： CHO Stable Cells
- 蛋白编码： P15391
- 应用性： ELISA
| 别称 |
B-Lymphocyte Antigen CD19;B-Lymphocyte Surface Antigen B4;CD19;CVID3;Differentiation Antigen CD19;T-Cell Surface Antigen Leu-12
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| 表达系统 |
CHO Stable Cells
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| 序列 |
Pro20-Lys291
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| 蛋白编码 |
P15391
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| 种属 |
Human
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| 计算分子量 |
57.3 kDa
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| 表观分子量 |
80-95 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Immobilized Human FMC63 at 2μg/ml(100 μl/well) can bind Human CD19-Fc. The ED50 of Human CD19-Fc is 55.28 ug/ml.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact; it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation; the cytoplasmic tail of CD19 becomes phosphorylated; which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency; hypogammaglobulinemia; recurrent bacterial infections and an inability to mount an antibody response to antigen.
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实验操作视频
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