Recombinant Human CD28 Protein(hIgG1 Fc Tag)
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- 表达系统： Mammalian
- 蛋白编码： P10747-1
| 别称 |
PAS;T-cell-specific surface glycoprotein CD;CD28;Tp44;CD28 antigen;CD28 molecule;GPSAT;GYPA;HGpMiX;MNS;PAS2;T-cell-specific surface glycoprotein CD28;T44
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| 表达系统 |
Mammalian
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| 序列 |
Asn19-Pro152
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| 蛋白编码 |
P10747-1
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| 种属 |
Human
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| 计算分子量 |
39.6 kDa
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| 表观分子量 |
55-70 kDa
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| 标签 |
C-hIgG1 Fc
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis
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| 背景 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
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实验操作视频
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