Recombinant Human CD30L Protein(Fc Tag)
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- 表达系统： Mammalian
- 蛋白编码： P32971
| 别称 |
CD153;CD153 antigen;CD30 antigen ligand;CD30 L;CD30 ligand;CD30-L;CD30L;CD30LG;MGC138144;TNFL8;Tnfsf8;Tumor necrosis factor (ligand) superfamily member 8;Tumor necrosis factor ligand superfamily member 8
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| 表达系统 |
Mammalian
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| 序列 |
Gln63-Asp234
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| 蛋白编码 |
P32971
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| 种属 |
Human
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| 计算分子量 |
43.8 kDa
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| 表观分子量 |
50-70 kDa
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| 标签 |
C-Fc
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 90% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 1.0 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
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实验操作视频
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