Recombinant Human CD68/SR-D1 (C-Fc)
Price:
- 表达系统： HEK293 Cells
- 蛋白编码： P34810
| 别称 |
CD68;CD68 antigenmacrophage antigen CD68;CD68 molecule;Macrosialin;SCARD1;SR-D1;SRD1;gp110
|
| 表达系统 |
HEK293 Cells
|
| 序列 |
Asn22-Ile320
|
| 蛋白编码 |
P34810
|
| 种属 |
Human
|
| 计算分子量 |
58.5 kDa
|
| 表观分子量 |
70-100 kDa
|
| 标签 |
C-Fc
|
| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
|
| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
|
| 制剂 |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
|
| 背景 |
CD68, also called Scavenger Receptor D1 (SR-D1) and LAMP-4, is a heavily glycosylated type I transmembrane glycoprotein that belongs to the LAMP family. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. CD68 is also a biomarker of rheumatoid arthritis and Hodgkin's lymphoma. CD68 influences the functions of cells through NF-kB/focal adhesion kinase pathway (7). In addition, CD68 on macrophages binds tightly to both S100A8 and S100A9 to enhance the cell immunity.
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Quantification and Site-Specific Analysis of Co-occupied N- and O-Glycopeptides
IF: 3.800Journal： JOURNAL OF PROTEOME RESEARCH (2024)
实验操作视频
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