Recombinant Human CLDN18.2(His & Avi Tag)
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- 表达系统： E.coli
- 蛋白编码： P56856-2
| 别称 |
CLDN18;Claudin-18.2
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| 表达系统 |
E.coli
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| 序列 |
extracellular
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| 蛋白编码 |
P56856-2
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| 种属 |
Human
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| 计算分子量 |
12.6 kDa
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| 表观分子量 |
13 kDa
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| 标签 |
N-His & C-Avi
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8M Urea, 150mM NaCl, 5mM β-ME, pH 8.5.
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| 复溶方法 |
Not Applicable
|
| 背景 |
Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2.IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is underinvestigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.
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Electrochemical immunosensor for the predictive cancer biomarker SLFN11 using reduced graphene oxide/MIL-101(Cr)-NH2 composite
IF: 7.700Journal： INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)
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