Recombinant Human CREB3L4 protein (His Tag)
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- 表达系统： E.coli
- 蛋白编码： Q8TEY5
| 别称 |
Androgen-induced basic leucine zipper protein (AIbZIP);Attaching to CRE-like 1 (ATCE1);CREB3L4;Cyclic AMP-responsive element-binding pr;Cyclic AMP-responsive element-binding protein 3-like protein 4;cAMP-responsive element-binding protein 3-like protein 4
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| 表达系统 |
E.coli
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| 序列 |
Glu14-Ser295
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| 蛋白编码 |
Q8TEY5
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| 种属 |
Human
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| 计算分子量 |
32.2 kDa
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| 表观分子量 |
40 kDa
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| 标签 |
N-His & C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95% as determined by reducing SDS-PAGE.
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| 内毒素 |
< 10 EU/mg of the protein as determined by the LAL method
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
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| 复溶方法 |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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| 背景 |
The cyclic AMP responsive element-binding protein 3-like 4 (CREB3L4) is a transcription factor highly expressed in multiple human cancers. This study aimed to investigate the regulatory effects of CREB3L4 on GC progression and angiogenesis. CREB3L4 was overexpressed in GC tissues and cell lines, and was positively correlated with advanced tumor stage and poor survival in GC patients. The upregulation of CREB3L4 in GC cells increased cell viability, promoted cell proliferation, reduced apoptosis, enhanced cell migration and invasion, and induced the formation of tubule-like endothelial structures, whereas CREB3L4 knockdown impeded tumor cell growth, attenuated cell motility, and prevented human umbilical vein endothelial cells from forming tubule-like structures. In addition, mice inoculated with CREB3L4-deficient GC cells showed significantly suppressed tumor growth compared to the group harboring wild-type tumors.
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实验操作视频
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