Recombinant Human CSF2RA/GM-CSFR Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P15509
- 应用性： Cell culture
| 别称 |
CD116;CDw116;CSF2R;CSF2RA;CSF2RY;GM-CSF-R-Alpha;GMCSFR-Alpha;GMR-Alpha;Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha
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| 表达系统 |
HEK293 Cells
|
| 序列 |
Glu23-Gly320
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| 蛋白编码 |
P15509
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| 种属 |
Human
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| 计算分子量 |
35.5 kDa
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| 表观分子量 |
60 kDa
|
| 标签 |
C-His
|
| 生物活性 |
Measured by its ability to inhibit GM-CSF-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.5-2 μg/ml.
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit α (CSF2RA) is a single-pass type I membrane protein which belongs to the type I cytokine receptor family of Type 5 subfamily. The CSF2RA gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes with some of the isoforms being membrane-bound and others being soluble. CSF2RA is a low affinity receptor for granulocyte-macrophage colony-stimulating factor. CSF2RA transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4).
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实验操作视频
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