UNQ;PRO;Death Receptor;Tumor Necrosis Factor Receptor Superfamily Member;TNFRSF;CD358;Death Receptor 6;Tumor Necrosis Factor Receptor Superfamily Member 21;DR6;TNFRSF21;UNQ437;PRO868; DR6;AA959878 Protein;BM 018;BM018;DR 6;DR6 Protein;MGC31965;OTTHUMP00000039915;R74815 Protein;TNFR related death receptor 6;TNFRSF 21;TNFRSF21 protein;TNR21;TR7 Protein;Tumor necrosis factor receptor superfamily member 21 precursor

Mammalian

Gln42-His349

O75509

Human

33.8 kDa

60 kDa

C-His

Not validated for activity

> 90% as determined by reducing SDS-PAGE.

< 1.0 EU/mg of the protein as determined by the LAL method

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

This product is provided as lyophilized powder which is shipped with ice packs.

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

TNFRSF21 (death receptor-6 , DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N-and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain , and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production , suggested that DR6 serves as an important regulatory molecule in T-helper cell activation , and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs , heart , brain and pancreas. Some tumor cells overexpress DR6 , typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion , which is subject to future investigations.