Recombinant Human Endoglin/CD105 Protein (His&Trx Tag)
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- 表达系统： E.coli
- 蛋白编码： P17813
| 别称 |
CD105;END;ENG;Endoglin;HHT1;ORW1
|
| 表达系统 |
E.coli
|
| 序列 |
Glu26-Gln176(Gly40Asp)
|
| 蛋白编码 |
P17813
|
| 种属 |
Human
|
| 计算分子量 |
33.6 kDa
|
| 表观分子量 |
34 kDa
|
| 标签 |
N-Trx-His
|
| 生物活性 |
Not validated for activity
|
| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
|
| 保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
| 运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
| 制剂 |
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
|
| 复溶方法 |
Not Applicable
|
| 背景 |
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins and/or other RGD receptors. Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1), which is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations.
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实验操作视频
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