M4S;MIC;M1S;DIAR;TROP;HNPCC;GA733;TACSTD;EGP;EPCAM;DIAR5;EGP-2;EGP314;EGP40;ESA;HNPCC8;KS1/4;KSA;M4S1;MIC18;MK-1;TACSTD1;TROP1;Ep-CAM;epithelial cell adhesion molecule;GA733-2;M1S2; MK-1; KSA; EGP40; TROP1;17 1A;323/A3;35-KD glycoprotein;Adenocarcinoma associated antigen;Adenocarcinoma-associated antigen;Antigen identified by monoclonal AUA1;AUA1;CD326;CD326 antigen;Cell surface glycoprotein Trop 1;Cell surface glycoprotein Trop 2;Cell surface glycoprotein Trop-1;chromosome 4;CO 17A;CO17 1A;CO17A;EGP 2;EGP2;Ep CAM;EpCAM1;Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD);Epithelial cell surface antigen;Epithelial cellular adhesion molecule;Epithelial glycoprotein;Epithelial glycoprotein 1;Epithelial glycoprotein 314;EpithelialGlycoprotein;GA733 1;GA733 2;gastrointestinal tumor-associated antigen 2;gp4;hEGP 2;hEGP314;Human epithelial glycoprotein 2;KS 1/4 antigen;KS 1/4 antigen.KSA;Ly74;Lymphocyte antigen 74;M1S 1;Major gastrointestinal tumor associated protein GA733 2;Major gastrointestinal tumor-associated protein GA733-2;mEGP314;Membrane component;Membrane component chromosome 4 surface marker (35kD glycoprotein);MK 1;Protein 289A;surface marker;surface marker 1;TACD1;Tumor associated calcium signal transducer 1;Tumor associated calcium signal transducer 2 precursor;Tumor-associated calcium signal transducer 1

Mammalian

Gln24-Lys265

P16422

Human

26.5 kDa

35 kDa

C-His

Not validated for activity

> 90% as determined by reducing SDS-PAGE.

< 1.0 EU/mg of the protein as determined by the LAL method

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

This product is provided as lyophilized powder which is shipped with ice packs.

Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Epithelial Cell Adhesion Molecule (EpCAM) , also known as GA733-2 antigen , is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region , a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage , high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However , recent insights have revealed that EpCAM participates in not only cell adhesion , but also in proliferation , migration and differentiation of cells. In addition , recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain , which can signal into the cell nucleus by engagement of elements of the wnt pathway.