Recombinant Human Fas/CD95/TNFRSF6 Protein (His Tag)
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- 表达系统： HEK293 Cells
- 蛋白编码： P25445
| 别称 |
ALPS1A;APO-1;APT1;Apo-1 antigen;Apoptosis-mediating surface antigen FAS;CD95;FAS1;FASLG receptor;FASTM;TNFRSF6 and FAS;Tumor necrosis factor receptor superfamily member 6
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| 表达系统 |
HEK293 Cells
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| 序列 |
Gln26-Asn173
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| 蛋白编码 |
P25445
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| 种属 |
Human
|
| 计算分子量 |
17.7 kDa
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| 表观分子量 |
22-35 kDa
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| 标签 |
C-His
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| 生物活性 |
Not validated for activity
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| 纯度 |
> 95 % as determined by reducing SDS-PAGE.
|
| 内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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| 保存条件 |
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
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| 运输条件 |
This product is provided as lyophilized powder which is shipped with ice packs.
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| 制剂 |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| 复溶方法 |
Please refer to the printed manual for detailed information.
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| 背景 |
FAS is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
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实验操作视频
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